Personalising treatment

People differ widely in their response to treatments, and what works for one person may not work for another.

We aim to investigate genetic, immunological and serological factors which may help us to understand these differences and allow us to achieve a more personalised approach to therapy.

We explore the questions:

• Do children with JIA who fail to respond to multiple drugs have a different underlying genetic architecture to the majority of JIA cases?
• Can we use genetics and immunological phenotypes to identify biological pathways which could be targeted with new or existing therapies?
• By measuring drug levels, can we tailor drug dose to an individual?